The canine brain has substantially more endocannabinoid receptors than most mammals, which increases the effects of this system. That’s why the beneficial effects are achieved with lower grams per kg of CBD.
The conditions where CBD has been anecdotally and clinically-demonstrated as helpful have been:
- Chronic pain conditions, as osteoarthritis and cancer
- Anxiety, stress and depression
- Acute seizures and epilepsy
- Diseases related to the immune system
- Aging related conditions, as cognitive dysfunction
As pure CBD oil (without THC) has little to no side effects, it’s preferred in patients with both chronic conditions or pain and metabolic disorders, liver disease or kidney disease, with careful observation from the veterinarian.
Clinical Studies and Empirical Evidence
A 2017 abstract conducting by Cornell University determined that “dogs with osteoarthritis receiving CBD oil are perceived to be more comfortable and active with very few undesirable side effects detected when compared to a placebo oil.”
In a 2018 publication, the American Animal Hospital Association outlined CBD use in dogs, its benefits, and current clinical studies that are being conducted. In this publication, Casara Andre, DVM, cVMA states in reference to CBD-related treatments for pets:
“I think we have the potential to gain access to a huge new side of our toolbox. One that, potentially, both complements everything we’re already doing, as well as expands our ability to treat some conditions that we don’t have great resources for right now.”
As studies increase, more and more pet owners are praising the benefits of a holistic approach to their pets’ health through their own observed results.
And, at present, Colorado State University is studying CBD oil and its benefits in dogs, and the results are powerful, as seen in the video below.
Your Pet’s Endocannabinoid System
Watch this brief video to learn about your pet’s endocannabinoid system and cannabinoid receptors found in their body:
Cannabidiol has no specific affinity for CB1 or CB2 receptors, instead it acts as an antagonist (or temporary blocker) of this receptors. Due to this blockage, the cell synthesizes a greater amount of CB1 receptors, enhancing their function.
It’s also an antagonist of receptors for neurotransmitters related to aggression and stress response, without increasing the number of receptors.
It has affinity for a specific receptor for serotonin, activating similar effects to this hormone: antidepressant, anxiolytics and neuroprotective effects.
CBD also inhibits the fatty acid amide hydrolases, the enzymes that degrade the endocannabinoids in the synaptic cleft, hence the ECB stay active in the synapse for more time and prolong and enhances their functions.
After arriving to the central nervous system through the bloodstream, it has a medium life of 9 to 18 hours, depending on its route of administration and its concentration. When administered with THC, inhibits THC destruction.
Recommended Organic CBD Products
Study: Cornell University finds “dogs with osteoarthritis receiving CBD oil are perceived to be more comfortable and active with very few undesirable side effects detected when compared to a placebo oil.”